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Why Should I Stop Taking NMN?

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NMN (Nicotinamide Mononucleotide) claims to contain anti-ageing properties. However, there have been claims and controversies surrounding the usage of Nicotinamide Mononucleotide.

Some people claim that NMN has the potential to delay aging signs, suppress weight gain, improve metabolism, and support blood sugar control.

However, the FDA’s involvement in regulating NMN has sparked concerns and raised doubts about the safety and efficacy of NMN supplementation. So, you might wonder if NMN is worth a try.

This article will explore NMN’s efficacy in supporting energy metabolism and overall vitality. It will also discuss the safety profile of NMN, why people are refraining from taking exogenous NMN, and the recent legal status of NMN.

What Is NMN?

Nicotinamide Mononucleotide is a precursor for nicotinamide dinucleotide (NAD), which influences metabolism and energy production.

When the body lacks adequate NMN, the production of NAD is compromised. It may lead to fatigue, brain fog, muscle weakness, or an increased risk of developing degenerative diseases.

NMN is a naturally occurring molecule present within the human body. It may regulate energy for physiological functions and comprises nucleotides, the building blocks of DNA.

NMN may potentially reverse aging signs, suppress metabolic disorders, and support immune function. It may boost NAD levels, which improves athletic performance, enhance metabolic rate, and increase mitochondrial metabolism.

NMN Significance
Naturally occurring molecules in the body Essential for DNA building blocks
Precursor for NAD Vital for metabolism and energy production
Boosts NAD production Enhances physiological functions and cellular processes
Supports overall health and well-being Enhances energy levels and supports a healthy lifestyle

NMN Taking

Safety Profile Of NMN

The safety profile of NMN formulations requires more research-backed evaluation and has limited data availability. Despite some positive safety indications, there are still potential health risks associated with NMN consumption.

Research studies indicated that consuming NMN supplements may induce minor side effects like gastric issues, diarrhea, and mild stomach pain in some people. These adverse effects are often attributed to certain ingredients like vitamins and minerals present in NMN formulations.

The response to NMN consumption may vary among people based on factors like overall health, existing medical conditions, and genetic predispositions. You should consult a doctor before considering prolonged NMN usage to minimize the risk of potential interactions.

Why I Stopped Taking NMN?

I discontinued my NMN supplementation regimen due to the lack of conclusive scientific evidence supporting NMN’s efficacy in maintaining overall well-being.

Upon deeper investigation, I discovered that essential nutrients for NMN production are readily available in natural sources like green vegetables, tomatoes, and avocados. This made me question the necessity of synthetic NMN supplementation.

Concerns over the FDA’s stance on NMN and the absence of clear regulatory approval influenced my choice to opt for natural substitutes for NMN.

Reasons for Discontinuing NMN

The decision was primarily influenced by safety concerns surrounding NMN. These included reported side effects, lack of proven efficacy, and health consequences of long-term NMN use.

The recent FDA ban on NMN that it cannot be lawfully marked as a dietary formulation raised red flags and prompted a reevaluation of the potential risks of NMN consumption.

I experienced minor side effects upon consuming NMN, including dizziness, headaches, and nausea. These were a cause for concern as they could impact my overall well-being. The lack of concrete evidence supporting NMN’s effectiveness further contributed to my decision to discontinue its use.

Thus, weighing these factors, I made the informed choice to halt my NMN supplementation regimen.

Advantages Of NMN

NMN could improve athletic performance by enhancing energy metabolism and mitochondrial function. Such effects may improve physical endurance and stamina.

It may promote general wellness by improving insulin sensitivity and blood sugar levels and mitigating stress and inflammation. NMN also possesses anti-aging properties, such as lengthening telomeres associated with slowing down the aging process.

NMN might boost the NAD concentration in the body, which enhances metabolic rate, supports cellular health, and improves eye function. Its impact on energy metabolism and insulin sensitivity may contribute to maintaining a healthy weight.

However, the potential health risks and lack of scientific backing may raise concerns about NMN’s effectiveness.


In 2015, the FDA warned a company of lacking scientific evidence to support NMN’s purported benefits. Subsequently, the FDA banned NMN as a dietary supplement in the US in December

2022, citing the need for further investigation into its risks and benefits.

This decision stemmed from the FDA’s responsibility to investigate NMN’s potential risks and benefits. The FDA’s ban on NMN aligns with DSHEA, or Dietary Supplement Health and Education Act of 1994. The Act requires substantial clinical investigations to support the marketing of supplements like NMN.

As a result, reputable manufacturers have halted NMN production in compliance with the FDA’s regulatory stance.

What Changes Occur After Stopping NMN?

After discontinuing NMN (nicotinamide mononucleotide) intake, physiological changes that could impact the anti-aging benefits associated with NAD+ levels may occur.

  1. Diminished Anti-Aging Effects: NMN is believed to boost NAD+ levels, which decline with age. NAD+ may support cellular processes and energy metabolism. With reduced NMN concentration, NAD+ levels may decrease, potentially reducing the anti-aging effects.
  2. Lessened Benefits: The potential NMN benefits, like improved energy, exercise endurance, and metabolism, are linked to NAD+’s role in energy production. These benefits may decrease with the cessation of NMN intake.
  3. Slowed Cellular Repair and Neuroprotection: Cellular repair and regeneration processes and neuroprotective effects attributed to NMN may slow down. These effects may diminish without continuous NMN supplementation.

Can NMN Supplements Cause Cancer?

Research suggests that NMN may fuel tumor growth in specific cancer types by increasing cellular NAD+ concentrations. A 2021 mouse study indicated that while NMN did not directly increase tumor size, it did lead to concerning changes in cancer markers.

Other studies suggest that NMN might help inhibit tumor development by enhancing immune cell function to target cancer cells more effectively.

Due to this mixed evidence, doctors might suggest people with active cancer or at high risk of cancer for NMN supplementation with caution until more conclusive human trials are conducted.

Frequently Asked Questions

  • Can NMN Interact With Other Medications or Supplements?
    NMN has minimal drug interactions. However, NMN formulations may contain other herbal ingredients that might interact with medications or supplements. Therefore, consult a doctor before combining NMN with other substances to ensure safety.
  • Are There Any Specific Lifestyle Changes Recommended When Taking Nmn?
    When taking NMN, specific lifestyle changes like maintaining a nutritious diet, regular exercise, and adequate hydration are recommended. These adjustments may complement NMN’s potential benefits for overall health and well-being.
  • How Long Does It Take to See Noticeable Benefits From NMN Supplementation?
    Some people may observe positive outcomes within two to three weeks of taking NMN, while others may take a few months to observe noticeable benefits. Results may vary based on age, metabolism, health status, and dosage.
  • Are There Any Age Restrictions or Limitations for NMN Supplementation?
    People below 18 years of age, nursing mothers, breastfeeding women, and those with underlying medical concerns should seek a doctor’s consultation before taking NMN.
  • Are There Any Specific Diet Recommendations to Maximize the Effects of Nmn?
    Specific dietary recommendations could optimize NMN effects. Focus on a nutritionally adequate diet rich in lean proteins, vegetables, fruits, and whole grains.


You should carefully decide whether NMN consumption is feasible for you. The lack of evidence-based backing, non-FDA approval status, and potential health risks associated with NMN use may raise concerns.

These factors may undermine the potential advantages of using NMN, like its anti-aging benefits and energy-boosting claims. You must weigh the evidence and consult a doctor before deciding whether to continue or cease NMN intake.

Exercising regularly, limiting overexposure to sun rays, following a ketogenic diet, and practicing intermittent fasting are some natural measures to boost NAD+ levels.

  • The information in this article is for informational purposes only and should not be considered medical advice.
  • It is not recommended to disregard/delay seeking professional medical advice or treatment because of what you read or accessed through this article.
  • The results may vary from individual to individual.
  • It is recommended to consult your doctor for any underlying medical conditions or if you are on any prescribed medicines before trying any tips or strategies.
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