Home » Andarine (S4) Reviews : Results, Side-Effects, Alternatives [Warnings Update]

Andarine (S4) Reviews : Results, Side-Effects, Alternatives [Warnings Update]

Andarine Review
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Classified as a SARM (selective androgen receptor modulator), Andarine S-4 claims to increase muscle mass, improve bone density, and enhance athletic performance. It was originally developed to manage conditions like muscle wasting and osteoporosis.

Andarine S-4 supposedly binds to androgen receptors, signaling the body to build muscle and bone tissue. However, it may induce unfavorable side effects, which may raise concerns about its safety.

Andarine S-4 was initially used in managing conditions like cachexia (severe muscle and weight loss) and osteoporosis.

However, Andarine S-4 lacks adequate clinical trials to verify its effectiveness in improving age-related muscle loss and athletic performance.

Long-term and potential side effects of using Andarine S-4 may include a yellowish vision, hormonal imbalance, possible liver damage, insomnia, and mood swings. The FDA and WADA do not approve Andarine S-4 for use in humans due to their adverse health effects.

In this Andarine S-4 review, we will scrutinize Andarine S-4’s function in improving muscle growth and performance and explain the possible dangers associated with this investigational SARM.

This review is based on Andarine S-4’s working mechanism, benefits, potential drawbacks, usage guidelines, consumer reviews, and more.

What Is Andarine S-4?

Andarine S-4 is an investigational drug belonging to the SARM class. It is orally bioavailable, making it more convenient to use than other SARMs, which require injections.

It may promote protein synthesis by mimicking the effects of testosterone, a primary male sex hormone that regulates muscle growth, energy, and strength. Andarine S-4 is popular among fitness enthusiasts and bodybuilders due to its anabolic (muscle-building) potential.

Andarine S-4 might support fat oxidation, helping convert stored fat into usable energy. It may help reduce body fat and might preserve lean muscle mass during cutting phases. It could also improve strength and endurance, potentially enhancing athletic performance.

Unlike anabolic steroids, which bind to androgen receptors throughout the body, Andarine S-4 supposedly targets specific muscle tissues to enhance muscle growth. Its selective nature is believed to help avoid some of the side effects associated with steroids.

However, most claims about Andarine S-4 benefits are based on anecdotal evidence rather than clinical studies. Depending on the region, the legality of Andarine S-4 varies.

Andarine Review

How Does Andarine S-4 Work?

Andarine S-4 functions by binding to specific androgen receptors, primarily in muscle and bone tissues. The selective action may support muscle growth and minimize the negative effects associated with anabolic steroids, such as those on the prostate and other organs.

When Andarine S-4 binds to androgen receptors, it could promote protein synthesis by nourishing the muscle cells. It might help accelerate muscle growth and repair, reduce muscle breakdown, and minimize soreness after intensive exercise sessions.

Andarine S-4 may increase the rate at which the body burns fat, potentially reducing overall body fat percentage. It might help those seeking weight loss, a leaner physique, or improved body composition.

Besides muscle growth, the selective binding of Andarine S-4 to androgen receptors in bone tissues may increase bone density and strength. Such effects might help those with osteoporosis or other bone-related conditions.

Even though Andarine S-4 provides muscle gain and performance benefits, it is a SARM that carries concerning side effects. It may cause potential health interactions like low testosterone levels, high blood pressure, gastrointestinal issues, and decreased libido.

Therefore, the exhaustive list of side effects, the FDA’s stance on Andarine S-4, and negative user reviews may raise concerns about its safety and effectiveness.

Andarine S-4 Benefits

  1. Increases Lean Muscle Mass

    Andarine S-4 may target specific tissues like muscle and bone, promoting growth in these areas. It could signal the body to produce more testosterone, positively impacting muscle growth, recovery, and strength.

    Andarine S-4 could bind to androgen receptors in muscle cells, activating specific pathways that enhance protein synthesis. Such effects may result in muscle tissue growth and improved muscle size.

    Having increased lean muscle composition could help your body burn more fat and calories, supporting weight loss. It could also boost metabolism, improve joint health, and increase overall strength.

  2. Burns Body Fat

    Andarine S-4 may promote lipolysis, the process of breaking down stored fats (triglycerides) into free fatty acids and glycerol. Such a mechanism may reduce excess fat deposits, which might assist in reducing body fat percentage.

    Supporting lean muscle growth, Andarine S-4 could increase the basal metabolic rate (the calories burnt at rest). Its ability to maintain a higher muscle-to-fat ratio could support fat loss.

    Lowering body fat levels might reduce the risk of developing chronic diseases like heart disease, fatty liver disease, or type 2 diabetes. It also helps improve mobility, reduce joint strain, and improve mood and sleep quality.

  3. Enhances Bone Density

    Andarine S-4 may bind to androgen receptors (in bone tissues) and mimic the effects of natural androgens on bone health. It may stimulate the osteoblasts (cells that promote bone formation), which improves the bone matrix and enhances bone density and strength.

    Calcium is a major constituent of bone tissue, and its proper deposition strengthens bones and improves their density. Andarine S-4 positively influences calcium metabolism, providing such benefits.

    Enhanced bone density leads to stronger bones, which are less susceptible to fractures and other injuries. It could help minimize the likelihood of developing bone-related conditions like osteoporosis, which is marked by brittle and weak bones.

Side Effects Of Using Andarine S-4

  1. Liver Damage

    There could be a potential correlation between prolonged use of Andarine S-4 and liver damage concerns. The liver metabolizes Andarine S-4, which might strain the liver, especially with prolonged or high-dose use.

    Signs of liver damage associated with Andarine S-4 use may include abdominal pain, jaundice, persistent fatigue, dark urine, or frequent digestive issues. Monitoring liver enzymes through regular tests could help detect any problems early on.

    Risk Factors Signs of Liver Damage
    Prolonged Andarine Use Jaundice
    High Dosages Abdominal Pain
    Concurrent Medications Fatigue
  2. Sleep Disorders

    Using Andarine S-4 may cause disruptions in sleep patterns, potentially resulting in sleep disorders. You might encounter difficulty falling or staying asleep, frequent awakenings throughout the night, and restlessness at night after taking Andarine S-4.

    Some users may encounter increased stress or anxiety levels when using Andarine S-4. Elevated stress and anxiety could disrupt the sleep-wake cycle, leading to sleep difficulties and potential sleep disorders.

    Sleep disorders induced by Andarine S-4 might result in excessive daytime sleepiness, affecting productivity and alertness. You may find yourself tossing and turning during the night, experiencing a restless quality of sleep.

  3. Lower Testosterone Levels

    SARMs like Andarine S-4 may suppress gonadotropin levels, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Such effects may reduce the body’s ability to stimulate testosterone production, leading to low T levels.

    Testosterone is a vital hormone that regulates various functions, including muscle growth, bone density, and libido. When testosterone levels drop, you may experience symptoms like increased tiredness and fatigue, decreased muscle mass, and mood changes.

    Decreased testosterone levels from using Andarine S4 might be concerning, especially for those who rely on adequate testosterone levels for athletic performance or overall well-being.

  4. Yellowish Vision

    High doses of Andarine S-4 are associated with common complaints of impaired vision and eye discomfort. You might experience a yellowish tint in vision, which may affect color perception, especially in low-light settings.

    The retina contains specialized cells called rod cells, which maintain vision in low-light conditions. Andarine S-4 may negatively interact with these cells, affecting their function and leading to vision difficulties in low-light environments.

    Some users could also encounter vision flashes, which may be disruptive and concerning. Impaired vision might affect daily activities and could persist even after discontinuing Andarine S-4 use.

  5. High Blood Pressure

    High blood pressure (also called hypertension) may occur when the blood exerts significant force against the arterial walls. Andarine S-4 might contribute to such an issue by negatively impacting the cardiovascular system.

    Elevated blood pressure may strain the heart, arteries, and other organs. It could potentially increase the risk of developing severe health concerns like stroke, kidney problems, and heart disease.

  6. Digestive Issues

    Some users may experience changes in appetite while using Andarine S-4, which may lead to digestive issues like bloating, stomach discomfort, or gas. It might disrupt the body’s hormonal balance, potentially causing nausea or stomach cramps.

    Andarine S-4 might alter bowel movements, affecting regularity and consistency. It could induce adverse gastrointestinal reactions like diarrhea, indigestion, heartburn, stomach discomfort, or vomiting.

  7. Mood Swings

    Andarine S-4 binds to androgen receptors in various tissues, including the brain. It may negatively impact neurotransmitters that regulate mood, such as serotonin and dopamine.

    Mood changes associated with Andarine S-4 may accompany irritability, anxiety, agitation, emotional instability, depression, or mental confusion. These mood changes may be unsettling for those who are not prepared for such effects.

    You should monitor mood changes and seek medical guidance if significant shifts occur. While some users may experience pronounced mood swings, others may not encounter such effects at all.

    Factors like dosage, duration of use, and overall health status may influence the extent to which mood swings manifest.

Is Andarine S-4 Legal?

FDA does not approve Andarine S-4 and other SARMs for human use. Andarine S-4 falls under the category of unapproved drugs, and its sale for human consumption is prohibited in the USA. The bodybuilding products that have SARMs raise serious safety concerns and cause heart stroke and liver damage.

The table below summarizes the legal aspects of Andarine S-4:

Aspect Legality Status Details
Sale for Research Legal May be sold and bought for research purposes online.
Human Consumption Illegal Illegal to sell in capsule form for human use or as dietary supplements.
Marketing as Supplements Illegal SARMs cannot be marketed as dietary supplements or with unapproved claims.
FDA Approval Not approved Still under investigation and not approved for general human use by the FDA.

Consumer Responses To Andarine S-4

Most Andarine S-4 users observed little to no benefits after using the SARM. The exhaustive list of potential side effects overshadowed any possible benefits derived from it.

Several consumers experienced side effects after taking Andarine S-4. They observed adverse health interactions like hormonal imbalances, yellow-tinted vision, sleep disturbances, frequent mood swings, and high blood pressure.

Many users shared their dissatisfactory experiences with Andarine S-4. They observed no significant muscle gains, reduced libido, water retention, and unfavorable appetite changes.

Andarine S-4 has the potential to cause damage to the kidneys and liver. It may induce water retention, negatively impacting kidney health. Prolonged use of Andarine S-4 may also increase the risk of chronic liver damage.

It has received mostly negative reviews, which raise concerns about its effectiveness and safety. Commonly observed side effects of Andarine S-4 include stomach pain, vision difficulties, bowel irregularities, digestive discomfort, and decreased testosterone levels.

Andarine S-4 is classified as an investigational SARM, which the FDA bans for human consumption. The FDA’s stance on Andarine S-4 aligns with the adverse side effects and potential health risks posed by Andarine S-4.

Andarine S-4 Alternative

Andarine S-4 claims to support muscle growth and improve athletic performance. However, it often fails to deliver the advertised benefits and may induce concerning side effects and potential health risks.

Developed by BrutalForce, Andalean could be a safer and legal substitute for the SARM Andarine S-4. Andalean aims to optimize workout performance by providing better muscle and strength gains, reducing body fat, and promoting faster recovery between workouts.

Andalean mimics the effects of Andarine S-4 without the accompanying side effects. It may help increase muscle mass and burn excess fat deposits.

The makers state that Andalean is suitable for anyone above 18 years old, helping them pack on lean muscle, boost energy, and improve body composition.

Andalean could improve energy levels and strength by triggering phosphocreatine synthesis within the muscle tissue.

According to the official site, Andalean contains natural components like soy protein isolate, whey protein isolate, and BCAA 2:1:1 (L-leucine, L-isoleucine, and L-valine). These ingredients may reduce muscle soreness and fatigue and lower blood sugar to minimize fat gain.

Unlike Andarine S-4, BrutalForce’s Andalean could be legally accessible, providing you with a natural alternative for your fitness and performance needs. The makers claim a strong safety profile, as Andarine S-4 is produced in the US in FDA-compliant and GMP-certified lab facilities.

Considering these factors, BrutalForce’s Andalean appears to be a promising substitute for the SARM Andarine S-4. Andalean has a natural formulation and research-backed formula, does not require a prescription before use, and has minimal side effects.

Frequently Asked Questions

  • Can Andarine S-4 Be Detected in Standard Drug Tests?
    Andarine S-4, belonging to the SARMs drug class, might not be detectable in standard drug tests due to its unique characteristics. However, specific tests like Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analyses are designed for SARM detection.
  • Is Andarine S-4 Safe As A Performance Enhancer In Sports?
    Andarine S-4 could enhance athletic performance. However, its use is banned by most sports organizations due to its classification as a performance-enhancing drug. Athletes should avoid it to comply with anti-doping regulations.
  • What Are The Signs Of Testosterone Suppression From Andarine -S4?
    Using Andarine S-4 may induce signs of testosterone suppression, such as fatigue, decreased libido, mood swings, and reduced muscle mass.
  • Is Andarine S-4 Linked To Mood Disorders Like Depression?
    Some users report mood swings or increased aggression while taking Andarine S-4, which could exacerbate underlying mood disorders like depression or anxiety.
  • Does Andarine S-4 Interfere With Fertility?
    Andarine S-4 may suppress natural testosterone production, which could affect fertility in men.
  • Can Andarine S-4 Worsen Sleep Apnea Symptoms?
    Andarine S-4 could disrupt sleep patterns, potentially exacerbating symptoms of sleep apnea in people with sleep disorders.
  • Are There Any Safer Alternatives For Andarine S-4?
    Andalean, by BrutalForce, may be a safer and more effective substitute for the SARM Andarine S-4. It contains natural, research-backed ingredients that could mimic the anabolic effects of Andarine S-4 minus the side effects.


Andarine S-4 was initially found to be useful in managing age-related muscle loss and osteoporosis. Subsequently, it was used to improve muscle gains, recovery, and athletic performance. However, Andarine S-4 use comes with an exhaustive list of side effects and health risks.

Andarine S-4 usage may pose concerning health risks as it increases the possibility of experiencing vision problems, sleep disturbances, hypertension, low testosterone levels, mood swings, and gastrointestinal interactions.

Andalean by BrutalForce could be a safer and more effective substitute for Andarine S-4. Andalean’s natural formula, along with positive customer reviews and the absence of side effects, may provide a safer and legal alternative to Andarine S-4.

Increase your training volume, consume protein-rich foods, focus on the eccentric phase of exercises, and get enough sleep. Following these tips could promote quality muscle gains and potentially improve athletic performance.

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